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Gluco Guardian Review: Will This Supplement Work For You?

Are you struggling to maintain your energy levels? Do you feel your productivity slipping away post-lunch? Besides energy crashes, are you prone to brain fog and irritability? Well, one team maintains that these might all be signs of dramatic fluctuations in blood sugar levels. Though food intake and lifestyle choices cause levels to spike and drop, not everyone is aware of the impact of physical and emotional stress triggers.

These triggers can cause a continued hormone shift, increasing blood sugar levels. In such cases, individuals must seek medical assistance and testing while considering add-on therapies. Why add-on therapies, you ask? To understand this, individuals must first familiarize themselves with Gluco Guardian.

What is Gluco Guardian?

Gluco Guardian is an all-natural blood sugar support formula. The creators claim to have curated this formula with healthy blood sugar in mind, sustainable energy levels, accelerated metabolism and enhanced sharp thinking. When taken as directed, Gluco Guardian could liberate individuals from constantly battling mid-day energy crashes, brain fog, and irritability – ultimately replacing these consequences with “renewed vitality and lasting clarity.”

However, the creators did not present their strategy behind Gluco Guardian at the time of writing; however, we do know the contents of this formula. Naturally, our editorial team worked to get to the foundation of Gluco Guardian. The subsequent section will cover the ingredients found in each serving.

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What does each Gluco Guardian serving consist of?

The Gluco Guardian consists of a 200-mg proprietary herbal blend filled with:

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Maca Root Extract

Maca is a plant that originates in the Peruvian Andes mountains. Its root, which consists of vitamins, minerals, macamides, macaridine, alkaloids, and glucosinolates, is responsible for the known benefits. Regarding Gluco Guardian, maca root may have been added to offset low mood and energy.

Studies have demonstrated that maca root might help regulate exercise-induced tiredness and improve mood. Nevertheless, these preliminary results must be taken lightly, as quality studies are still needed to make firm generalizations. Other initial findings from animal studies include preserved cognitive function, anti-inflammatory effects, and improved nutrient digestion.

Grape seed Extract

Grape seed extract (GSE) [2] is derived from pulverizing whole grape seeds. Its rich source of antioxidants must be highlighted, especially since it contains phenolics, anthocyanins, flavonoids, and oligomeric proanthocyanidin complexes (OPCs). One study [3] that looked at the effects of GSE on high-risk cardiovascular markers in patients with type 2 diabetes found that the extract improved markers of inflammation and glycemia, both of which contribute to oxidative stress in obese patients.

Put differently, GSE might help decrease cardiovascular risk. A 2024 study [4] confirmed that Iranian GSE consumption over a short period lowered fasting blood sugar levels and systolic blood pressure in patients with type 2 diabetes mellitus. These results are attributed to its proanthocyanidin content.

Guarana Seed Extract

Guarana seed extract [5] is made from a plant native to the Amazon. It is best known for its high caffeine content and chemicals such as theophylline and theobromine. Together, this trio has the potential to stimulate the central nervous system, heart, and muscles. Interestingly, this ingredient also contains antioxidants, which have been proven to lessen the damaging effects of free radicals on the body. Some studies have also noted that the plant might improve “memory, attention, alertness, and reaction time.” That said, more research is needed to understand an effective dosage.

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African Mango Fruit Extract

African mango, or Irvingia gabonensis, is a greenish-yellow fruit with a high-fiber pulp and a hard seed. The pulp and seed have been historically used in Nigerian and Cameroonian cuisines. Given that the pulp contains vitamin C and carotenoids, it is safe to assume that this ingredient might exhibit antioxidant capacity. Aside from this, African mango extract (AME) might inhibit the growth of fat cells, thereby increasing weight loss efforts. Alas, existing studies are mediocre, warranting more human studies. We already know that AME could reduce waist circumference, body fat, blood sugar levels, bad cholesterol, and triglyceride levels.

Eleuthero Root Extract

Eleuthero [7] is a woody shrub that grows predominantly in northeast Asia. It is renowned for its adaptogenic properties, meaning that it helps the body overcome external and internal stressors. Many of its plant compounds, such as saponins, flavones, and eleutherosides, are believed to contribute to several health benefits. Of potential interest to Gluco Guardian is its effect on cholesterol levels. A relatively small study was referenced in the same source, arguing that eleuthero might significantly lower harmful cholesterol levels. At the same time, the researchers found fewer signs of lymphocytes, which might imply fewer oxidative stress markers.

Another source [8] that looked at the effects of eleuthero on overall well-being listed 12 potential benefits from animal and human studies. Of the 12, a couple stood out. Precisely, we are referring to eleuthero’s ability to increase energy levels, reduce fatigue, improve cognitive function (by increasing blood flow to the brain), increase exercise performance, and reduce insulin resistance (by lowering fasting and post-meal blood sugar levels).

Astragalus

Astragalus, or Huang Qi, is a traditional Chinese herb administered to boost the immune system, improving heart and kidney functions, and lowering blood sugar levels. In the context of blood sugar levels, one source referenced the general findings of animal and test-tube studies. Researchers found the primary impact of Astragalus polysaccharides (APS) on diabetes is a decrease in insulin resistance and sugar metabolism and reduced blood sugar levels by improving intestinal barrier function and immunity for possibly triggering weight loss.

Although more human research is still needed on this front, other possible benefits include improved kidney function and relief from symptoms of chronic fatigue.

Green Tea Leaf Extract

Green tea leaf extract is from the Camellia sinensis plant. It is considered a great source of antioxidants, reducing the negative effects of free radicals on the body while possibly tending to other areas, including heart, liver, skin, and brain functions. Starting with heart health, this ingredient has been proven to decrease inflammation, lower blood pressure, and reduce blood fat levels. Antioxidants, namely EGCG, have also been demonstrated to protect brain cells from oxidative stress. This means reduced risk of mental decline, memory loss, and the development of brain diseases.

A popular outcome linked to green tea consumption is weight loss. In particular, combining caffeine and catechins might assist in weight loss by triggering thermogenesis. Alas, this might not translate to most races or body types. In blood sugar management, green tea leaf extract was found in rat studies to enhance insulin sensitivity and greatly decrease fasting blood sugar levels.

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Gymnema Sylvestre

Gymnema Sylvestre is a woody climbing shrub native to tropical forests in India, Australia, and Africa. Its leaves have become a staple in Indian Ayurvedic medicine, especially for controlling symptoms of diabetes. So far, evidence suggests that Gymnema Sylvestre can block the taste of sugary foods from their sweetness, making them less appealing to individuals and helping them cut back on such intake.

Second, it is supposedly filled with anti-diabetic properties. Simply put, gymnema sylvestre might limit sugar absorption (lowering post-meal blood sugar levels), ensure proper use and increased production of the insulin hormone, and reduce the risk of heart disease by improving the composition of good and bad cholesterol and triglycerides.

Coleus Forskohlii Root Extract

Coleus forskohlii, or the Indian coleus plant, is an herbal remedy from the mint family. One source that looked at the effects of forskohlii on metabolic parameters of obese and overweight people found that forskolin promotes positive changes in body composition by significantly decreasing the percentage of body fat and fat mass and increasing bone mass. Another study states that it regulates the body’s thermogenic response to food, increases the body’s basal metabolic rate, and increases the utilization of body fat.

Other areas that have been studied include weight loss, reduction in asthma risks and eye pressure, blood pressure levels, and protection against glaucoma.

Capsicum Annuum Fruit Extract

Capsicum annuum, or red chili, is a hot chili pepper with a rich source of an active compound called capsaicin. Capsicum is best known for its ability to boost metabolism by increasing oxygen consumption and raising body temperature to burn calories. To our surprise, this ingredient also boasts anti-inflammatory properties, protecting individuals from the risk of developing autoimmune disorders and heart disease. Another study [15] looked at the effects of capsicum annuum on blood sugar levels. It stated that the ingredient might inhibit glucose absorption, which might partially help lower blood sugar levels.

Grapefruit Seed Extract

Grapefruit seed extract (GFSE) is a liquid concentration from the fruit’s seeds, pulp, and white membranes. GFSE, according to one source [16], contains a rich source of vitamin C, lycopene, limonoids, and pectin, all of which contribute to immune function, protection against tumor growth, cholesterol composition, and heart health. Regarding blood sugar management, grapefruit’s flavonoid, naringin, might be interesting. Precisely, it has been linked to improved symptoms of ketoacidosis in people with type 1 diabetes and decreased oxidative stress levels.

As such, researchers similarly believe that naringin might help those with type 2 diabetes. Other mechanisms through which blood sugar levels might be regulated include improved glucose tolerance, a decrease in the production of glucose in the liver, and improved glucose metabolism [16].

Panax Ginseng Root Extract

Panax ginseng [17] is a plant that grows in the mountains of East Asia. Its roots are usually harvested and consumed either as tea or added to supplements. Of the different health areas studied, this ingredient has been extensively studied in the context of blood sugar health. Many meta-analyses and systematic reviews have pointed to its ability to improve fasting glucose and postprandial insulin.

Aside from blood sugar, Panax ginseng might lower harmful cholesterol levels and inflammatory markers and relieve hot flashes.

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Raspberry Ketones

Raspberry ketone is a substance that gives the raspberry fruit its aroma. Most ketones found in supplements are synthetically manufactured to mimic the real deal. Intriguingly, Raspberry ketones contain two molecules comparable to capsaicin and a stimulant known as synephrine. Since these molecules significantly boost metabolism, researchers have assumed similar characteristics for raspberry ketones. Studies have confirmed that Raspberry ketones increase fat breakdown and release the adiponectin hormone.

The latter release is deemed imperative for regulating metabolism and blood sugar levels. Studies on adiponectin levels may be the answer to healthy blood sugar management.

L-Glutamine

L-glutamine [19] is an amino acid that contributes to protein synthesis. Interestingly, this specific amino has other functions, including altering blood sugar levels. In particular, as it makes its way to the bloodstream, it increases glucose production. To our amazement, cells in our livers and kidneys convert some glutamine into glucose through chemical reactions. So, naturally, levels should rise, right? According to the same source, glutamine might help decrease blood sugar levels by increasing glucagon peptide-1 (GLP-1) protein levels.

GLP-1 [19] works to increase insulin production (thereby helping to increase glucose uptake), reduce glucagon release from the pancreas (thereby reducing glucose production by the liver), and delay stomach emptying. This consequently slows down food absorption and prevents sudden peaks in blood sugar.

L-Tyrosine

L-tyrosine [20] is a type of amino acid that the body produces from another one called phenylalanine. It is primarily tasked with producing several substances such as dopamine (which regulates our pleasure and reward centers and contributes to memory and motor skills), adrenaline and noradrenaline (which trigger the fight-or-flight response in stressful times), thyroid hormones (critical for metabolism regulation), and melanin (gives our skin, hair, and eyes their color).

Another source [21] emphasized its ability to improve athletic performance, allowing individuals to engage in physical activities while increasing their reaction time fully. When supplemented with caffeine, available through other ingredients in Gluco Guardian, individuals can anticipate increased speed and precision in exercise movements.

L-Arginine

L-arginine is a semi-essential amino acid that is crucial under certain conditions. In the grand scheme, this amino acid has been repeatedly studied regarding nitric oxide production, which significantly impacts “blood flow regulation, mitochondrial function, and cellular communication,” reveals the author. Moreover, it acts as a precursor to other amino acids that boost immune function.

In addition to athletic performance (i.e., an increase in nitric oxide means increased oxygen delivery to the muscles), L-arginine has been proven to regulate high blood pressure levels and improve glucose metabolism and insulin sensitivity. Nitric oxide also helps cells respond to insulin, ensuring proper uptake.

Beta-Alanine

Beta-alanine [23] is an amino acid that the liver naturally produces and is essential for the production of carnosine in muscles and the brain. Without the latter, individuals are likely to experience fatigue, preventing them from fully engaging in physical activity. When paired, beta-alanine and carnosine might help lower fasting blood sugar levels and hemoglobin A1C (a blood sugar level measurement over the past three months).

Another recent study [24]that looked at the effects of carnosine or beta-alanine concluded similarly, adding that either component might also improve fasting insulin in humans, ultimately improving glycemic control and insulin resistance.

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Monoammonium Glycyrrhizinate

Monoammonium glycyrrhizinate, or glycyrrhetinic acid monoammonium salt, is a bioactive compound derived from licorice root. One study [25] that looked at the effects of glycyrrhizic acid and its derivatives on symptoms of type 2 diabetes mellitus reported promising effects. In particular, the researchers have expounded on its anti-inflammatory, antioxidant, anti-viral, immunoregulatory, anti-cancer, and anti-diabetic properties.

Speaking about anti-diabetic properties, this ingredient is believed to reduce glucose levels, decrease serum insulin levels, enhance insulin sensitivity, improve glucose tolerance and balance, and regulate fat metabolism.

Gamma-aminobutyric acid (GABA)

GABA [26] is a naturally available amino acid in the human brain. It works as an inhibitory neurotransmitter, ensuring healthy communication between cells. The supplementation version is meant to work similarly. By this, we mean a potential improvement in relaxation, pain relief, stress, anxiety, blood pressure levels, and sleep quality. Emerging research has also linked GABA supplementation to motility, inflammation, hormones, and immune system regulation.

A study [27] that examined the effects of pancreatic GABA on glycemic indices underlined that GABA acts on two different types of receptors: GABA-A and GABA-B. Furthermore, the researchers explained that glutamic acid produces pancreatic beta cells from GABA. As such, the study discovered that pancreatic GABA improves islet cell function, glucose homeostasis, and autoimmunity in patients with diabetes mellitus.

Additionally, it improved beta-cell survival (responsible for releasing insulin) and increased the conversion rate of alpha cells into beta cells. This led the team to believe that GABA might, in some magnitude, increase insulin sensitivity by activating GABA-A receptors [27].

L-Ornithine HCl

L-ornithine HCl [28] is a nonessential amino acid that still happens to make a difference in our existence. One source highlighted that the amino acid helps detoxify waste products before they leave the body, emphasizing ammonia. High levels of ammonia have since been linked to cognitive dysfunction and even personality changes, according to several studies. Aside from that, individuals can anticipate decreased recovery times after exercise, better management of chronic liver disease, wound healing, and quick hangover recovery.

L-ornithine and L-arginine are usually paired because the latter helps improve the former’s absorption levels.

L-Tryptophan

L-tryptophan is an essential amino acid that the body initially converts into 5-HTP and eventually into serotonin. Some might end up as nicotinamide adenine dinucleotide (NAD), critical for cellular functioning. Preliminary studies suggest this amino acid might promote quality sleep, relieve depression and anxiety symptoms, increase emotional well-being, and increase pain tolerance.

An outdated rat study [30] that examined the effects of L-tryptophan on blood sugar did find that it might suppress rising blood sugar levels while lessening the burden associated with insulin secretion from beta cells. However, these angles must be studied further to fully understand the underlying mechanisms.

L-Carnitine

The last amino acid and ingredient in the Gluco Guardian proprietary herbal blend is L-carnitine. Theoretically, L-carnitine is believed to increase energy production by transporting fatty acids into the cell’s mitochondria. This process can cause a slight reduction in body weight, body mass index, and fat mass. However, more research is needed to understand the long-term effects of L-carnitine supplementation.

Additionally, individuals might experience improvements in brain function, heart health, exercise performance, insulin sensitivity, and beta cell functioning, among other things.

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Frequently Asked Questions (FAQ)

Q. Who is Gluco Guardian suitable for?

A. Gluco Guardian is suitable for men and women between 30 and 70 looking for healthy blood sugar support. Since the formula is extensive, users are responsible for researching, especially if they are taking prescription medications with an increased interaction risk.

Q. Is Gluco Guardian safe?

A. Gluco Guardian appears safe to take, given that each serving contains a low dose of several ingredients. Most ingredients have been tested to some extent, with varying magnitudes of significance. Additionally, most of the ingredients have been well tolerated.

To further the safety of this supplement, the creators claim to have manufactured each bottle in the United States in an FDA-registered, cGMP-certified facility. It goes without saying that despite Gluco Guardian’s overall safety, individuals should take precautionary measures and speak to their doctor before getting started.

Q. Are there any side effects to taking Gluco Guardian?

A. At the time of writing, the creators insist that they have not received any reports of side effects. Should individuals feel uneasy after taking a serving, they are advised to stop using it immediately.

Q. How long will it take to see results with Gluco Guardian?

A. While the creators have not provided a timeframe for results, our research on the ingredients suggests that at least one month is required for the ingredients to kick in. For this reason, they seem to favor anywhere between 3 and 6 months of use.

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Q. How do I take Gluco Guardian?

A. The recommended serving size is one full dropper (1 ml) daily or as a healthcare professional directs.

Q. Does a money-back guarantee protect Gluco Guardian?

A. Yes, Gluco Guardian has been protected by a 60-day money-back guarantee. If, after 60 days of taking this supplement, individuals are still not convinced by the reported benefits, customer service can be contacted for a full purchase price refund. To see which purchases qualify, the best ways to get in touch with the team are listed below:

  • Email: support@getglucoguardian.com.
  • Phone: 1 (844) 680-1006
  • Mailing Address: Gluco Guardian, 7780 49th St., North Box, 513 Pinellas Park, FL 33718

How much does Gluco Guardian cost?

Each Gluco Guardian bottle contains a 30-day supply. Since a minimum of a month is required to see initial results, individuals may want to continue for at least six months before assessing its effectiveness. To make this a financially-friendly investment, the creators are offering Gluco Guardian at the following price points:

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  • 1 Gluco Guardian bottle: $89 each + applicable shipping
  • 3 Gluco Guardian bottles: $59 each + free U.S. shipping
  • 6 Gluco Guardian bottles: $49 each + free U.S. shipping

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Concluding Remarks

Based on the analysis above, Gluco Guardian is a blood support formula that works on a cellular level and simultaneously eases symptoms of fluctuating blood sugar levels. After examining each ingredient, our editorial team found that the formula could improve beta cell functioning (critical for releasing insulin into the bloodstream) and insulin sensitivity, delay stomach emptying, and increase GLP-1 production. All of these factors ease fasting and post-meal glucose levels.

Normally, people who struggle with fluctuating blood sugar levels also lack energy, experience brain fog, and feel irritable. Gluco Guardian has also addressed these issues, which is reassuring.

Our editorial team wondered why the creators focused on quantity rather than quality. If anything, a handful of ingredients with a role would have sufficed, especially given the low-dose nature of each serving.

Gluco Guardian consists of a proprietary blend, which could be seen as a drawback since users won’t know which ingredients are in higher concentrations and which are in lower amounts. However, we believe these are all important considerations to consider before placing an order.

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